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CHROMOSOMAL ANALYSIS:
Chromosomal Analysis
- Advanced maternal age
- Previous child or pregnancy with chromosomal abnormality
- Abnormal ultrasound
- Abnormal maternal serum screen
- Fetal demise
- Multiple miscarriage
- Mental retardation or developmental delay
- Dysmorphism
- Congenital anomalies
- Male or female infertility
G-band chromosomal analysis is performed on all blood specimens. High resolution analysis is performed when indicated. Additional chromosome banding techniques are utilized when necessary. Cell cultures are established from all amniotic fluid, chorionic villi, and tissue specimens followed by G-band chromosome analysis.
Prenatal Studies
Amniotic fluid: Collect 20 – 25 cc in a 50 ml sterile conical centrifuge tube.
Chorionic villi: Collect 15 – 20 mg villi in a T-25 tissue culture flask containing sterile tissue culture media.
Postnatal Studies
Blood: For adults and children, 3 – 5 cc collected in a sodium heparin (green top) vacutainer tube. For newborns, 1 - 2 cc is sufficient. Do not centrifuge or freeze. Store sample at room temperature.
Other Tissue Studies
Collect 5 mm tissue in sterile culture media.
Prenatal studies with cell culture: 7 - 10 days
Postnatal studies: 7 - 14 days
Other tissue studies with cell culture: 14 - 21 days
Blood: 88262, 88230, 88291
Amniotic fluid and chorionic villi: 88235, 88267, 88280, 88291
Other tissue: 88262, 88233, 88291
Alpha-Fetoprotein: 82106
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